Njar, V.C.O. : rechercher sur Z-Library

Derek V. Banthorpe, Stephanie A. Branch, Vincent C.O. Njar, Michael G. Osborne, Dvid G. Watson

Année:

2001

Fichier:

PDF, 28 KB

2001

Ability of plant callus cultures to synthesize and accumulate lower terpenoids

Journal:

Phytochemistry

Année:

1986

Langue:

english

Fichier:

PDF, 912 KB

english, 1986

Comprehensive Pharmacology and Clinical Efficacy of Aromatase Inhibitors

Vincent C. O. Njar, Dr Angela M. H. Brodie

Journal:

Drugs

Année:

1999

Langue:

english

Fichier:

PDF, 356 KB

english, 1999

Novel C-4 Heteroaryl 13- cis -Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice

Mbatia, Hannah W., Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Martin, Marlena S., Kwegyir-Afful, Andrew K., Njar, Vincent C. O.

Journal:

Njar, Vincent, Adesanwo, Julius, Raji, Yinusa

Année:

2015

Langue:

english

Fichier:

PDF, 3.92 MB

english, 2015

Methyl Angolensate: The Antiulcer Agent of the Stem Bark of Entandrophragma angolense

Journal:

Planta Medica

Année:

1995

Langue:

english

Fichier:

PDF, 167 KB

english, 1995

High-Yield Synthesis of Novel Imidazoles and Triazoles from Alcohols and Phenols

Njar, Vincent C. O.

Journal:

Synthesis

Année:

2000

Langue:

english

Fichier:

PDF, 131 KB

english, 2000

CYP17 Inhibitors for Prostate Cancer Treatment – An Update

Moreira, V., Salvador, J., Vasaitis, T., Njar, V.

Journal:

Current Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2008

ChemInform Abstract: Nucleophilic Vinylic “Addition-Elimination” Substitution Reaction of 3. beta.-Acetoxy-17-chloro-16-formylandrosta-5,16-diene: A Novel and General Route to 17-Substituted Steroids. Part 1. Synthesis of Novel 17-Azolyl-δ16 Steroids; Inhibitors of 17α-Hydroxylase/17, 20-Lyase (17α-Lyase).

V. C. O. NJAR, G. T. KLUS, A. M. H. BRODIE

Journal:

V. C. O. Njar, A. M. H. Brodie

Année:

1997

Fichier:

PDF, 36 KB

1997

ChemInform Abstract: Inhibitors of 17α-Hydroxylase/17,20-Lyase (CYP17): Potential Agents for the Treatment of Prostate Cancer

Journal:

Vincent C. O. Njar, Ivo P. Nnane, Angela M. H. Brodie

Année:

1999

Fichier:

PDF, 28 KB

1999

ChemInform Abstract: Potent Inhibition of Retinoic Acid Metabolism Enzyme(s) by Novel Azolyl Retinoids.

Journal:

Vincent C. O. Njar, Derek V. Banthorpe

Année:

2000

Fichier:

PDF, 26 KB

2000

Synthesis of (+) and (−) [10-14C]-α- and β-pinenes

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1985

Langue:

english

Fichier:

PDF, 272 KB

english, 1985

Cytochrome P450c17-ExpressingEscherichia colias a First-Step Screening System for 17α-Hydroxylase- C17,20-lyase Inhibitors

Dmitry N. Grigoryev, Katsuya Kato, Vincent C.O. Njar, Brian J. Long, Yang-Zhi Ling, Xin Wang, James Mohler, Angela M.H. Brodie

Journal:

Analytical Biochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 164 KB

english, 1999

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases

Vincent C.O. Njar, Lalji Gediya, Puranik Purushottamachar, Pankaj Chopra, Tadas Sean Vasaitis, Aakanksha Khandelwal, Jhalak Mehta, Carlic Huynh, Aashvini Belosay, Jyoti Patel

Journal:

Vincent C.O. Njar, Markus Hector, Rolf W. Hartmann

Année:

2006

Langue:

english

Fichier:

PDF, 926 KB

english, 2006

20-Amino and 20,21-aziridinyl pregnene steroids: Development of potent inhibitors of 17α-hydroxylase/C17,20-lyase (P450 17)

Journal:

Puranik Purushottamachar, Aakanksha Khandelwal, Pankaj Chopra, Neha Maheshwari, Lalji K. Gediya, Tadas S. Vasaitis, Robert D. Bruno, Omoshile O. Clement, Vincent C.O. Njar

Année:

1996

Langue:

english

Fichier:

PDF, 476 KB

english, 1996

First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents

Journal:

Robert D. Bruno, Vincent C.O. Njar

Année:

2007

Langue:

english

Fichier:

PDF, 856 KB

english, 2007

Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development

Journal:

Lalji K. Gediya, Aashvini Belosay, Aakanksha Khandelwal, Puranik Purushottamachar, Vincent C.O. Njar

Année:

2007

Langue:

english

Fichier:

PDF, 403 KB

english, 2007

Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts

Journal:

Puranik Purushottamachar, Aakanksha Khandelwal, Tadas S. Vasaitis, Robert D. Bruno, Lalji K. Gediya, Vincent C.O. Njar

Année:

2008

Langue:

english

Fichier:

PDF, 236 KB

english, 2008

Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent

Journal:

Journal of Chromatography B

Année:

2008

Langue:

english

Fichier:

PDF, 372 KB

english, 2008

Quantification of a novel retinoic acid metabolism inhibitor, 4-(1H-imidazol-1-yl)retinoic acid (VN/14-1RA) and other retinoids in rat plasma by liquid chromatography with diode-array detection

Chunyu Wu, Vincent Njar, Angela Brodie, Michael Borenstein, Ivo Nnane

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 105 KB

english, 2004

Synthesis of [16, 16, 19-2H3; 19-3H]19-oxo-androst-4-ene-3, 17-dione

V.C.O. Njar, H.R.W. Dharmaratne, E. Caspi

Journal:

Journal of Chromatography A

Année:

1988

Langue:

english

Fichier:

PDF, 470 KB

english, 1988

Light-dependent monoterpene synthesis in Pinus radiata cultures

Derek V. Banthorpe, Vincent C.O. Njar

Journal:

Phytochemistry

Année:

1984

Langue:

english

Fichier:

PDF, 530 KB

english, 1984

Enzymatic transesterification of steroid esters in organic solvents

Vincent C.O. Njar, Eliahu Caspi

Journal:

Tetrahedron Letters

Année:

1987

Langue:

english

Fichier:

PDF, 207 KB

english, 1987

Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids

Vincent C.O Njar, Ivo P Nnane, Angela M.H Brodie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 129 KB

english, 2000

Nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene: A novel and general route to 17-substituted steroids. Part 1 - synthesis of novel 17-azolyl-Δ16 steroids; inhibitors of 17α-hydroxylase/17, 20-lyase (17α-lyase)

Vincent C.O. Njar, Gregory T. Klus, Angela M.H. Brodie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 283 KB

english, 1996

Antiulcer activity of the stem bark extract of Entandrophragma angolense

V. C. O. Njar, J. K. Adesanwo, J. M. Makinde, O. B. Taiwo

Journal:

Phytotherapy Research

Année:

1994

Langue:

english

Fichier:

PDF, 232 KB

english, 1994

Pharmacokinetics of novel inhibitors of androgen synthesis after intravenous administration in mice

Ivo P. Nnane, Vincent C. O. Njar, Angela M. H. Brodie

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 253 KB

english, 2003

Murine toxicology and pharmacokinetics of novel retinoic acid metabolism blocking agents

Jyoti B. Patel, Aakanksha Khandelwal, Pankaj Chopra, Venkatesh D. Handratta, Vincent C. O. Njar

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 333 KB

english, 2007

Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice

Huynh, C K, Brodie, A M H, Njar, V C O

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 263 KB

english, 2006

MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN/66-1 in hormone-insensitive PC-3 prostate cancer cells and tumours

Khandelwal, A, Gediya, L K, Njar, V C O

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 319 KB

english, 2008

Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

Schayowitz, A, Sabnis, G, Goloubeva, O, Njar, V C O, Brodie, A M H

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 432 KB

english, 2010

Effects of new 17α-hydroxylase/C17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo

Grigoryev, D N, Long, B J, Nnane, I P, Njar, V C O, Liu, Y, Brodie, A M H

Journal:

Njar, Vincent C. O., Kato, Katsuya, Nnane, Ivo P., Grigoryev, Dmitry N., Long, Brian J., Brodie, Angela M. H.

Année:

1999

Langue:

english

Fichier:

PDF, 207 KB

english, 1999

Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17α-Hydroxylase-C17,20-lyase (P45017α): Potential Agents for the Treatment of Prostate Cancer

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 174 KB

english, 1998

Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model

Handratta, Venkatesh D., Vasaitis, Tadas S., Njar, Vincent C. O., Gediya, Lalji K., Kataria, Ritesh, Chopra, Pankaj, Newman, Donnell, Farquhar, Rena, Guo, Zhiyong, Qiu, Yun

Journal:

Gediya, Lalji K., Chopra, Pankaj, Purushottamachar, Puranik, Maheshwari, Neha, Njar, Vincent C. O.

Année:

2005

Langue:

english

Fichier:

PDF, 307 KB

english, 2005

A New Simple and High-Yield Synthesis of Suberoylanilide Hydroxamic Acid and Its Inhibitory Effect Alone or in Combination with Retinoids on Proliferation of Human Prostate Cancer Cells

Journal:

M. HECTOR, R. W. HARTMANN, V. C. O. NJAR

Année:

2005

Langue:

english

Fichier:

PDF, 120 KB

english, 2005

ChemInform Abstract: Pyridinium Dichromate: A Novel Reagent for the Oxidation of Steroidal . delta.5-3β-Alcohols to the Corresponding δ4-3,6-Diketones.

Journal:

Breast Cancer Research and Treatment

Année:

1996

Fichier:

PDF, 31 KB

1996

Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in theN-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus

Paul E. Goss, Shangle Qi, Haiqing Hu, Lalji K. Gediya, Puranik Purushottamachar, Abhijit M. Godbole, Vincent C. O. Njar

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 311 KB

english, 2012

Regulation of androgen receptor activity by tyrosine phosphorylation

Zhiyong Guo, Bojie Dai, Tianyun Jiang, Kexin Xu, Yingqiu Xie, Oekyung Kim, Issa Nesheiwat, Xiangtian Kong, Jonathan Melamed, Venkatesh D. Handratta, Vincent C.O. Njar, Angela M.H. Brodie, Li-Rong Yu,

Journal:

Cancer Cell

Année:

2006

Langue:

english

Fichier:

PDF, 768 KB

english, 2006

Regulation of Androgen Receptor Activity by Tyrosine Phosphorylation

Zhiyong Guo, Bojie Dai, Tianyun Jiang, Kexin Xu, Yingqiu Xie, Oekyung Kim, Issa Nesheiwat, Xiangtian Kong, Jonathan Melamed, Venkatesh D. Handratta, Vincent C.O. Njar, Angela M.H. Brodie, Li-Rong Yu,

Journal:

Cancer Cell

Année:

2007

Langue:

english

Fichier:

PDF, 41 KB

english, 2007

First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): Identification of novel RAMBA scaffolds

Puranik Purushottamachar, Jyoti B. Patel, Lalji K. Gediya, Omoshile O. Clement, Vincent C.O. Njar

Journal:

European Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2012

Biotransformation of progesterone to 14α-hydroxypregna-1,4-diene-3,20-dione, a novel fungal metabolite, by Colletotrichum antirrhini

V.C.O. Njar, S. Shapiro, T. Arunachalam, E. Caspi

Journal:

Journal of Steroid Biochemistry

Année:

1985

Langue:

english

Fichier:

PDF, 231 KB

english, 1985

Synthesis of C-2, 3, 17 and 19-oxygenated androgens

Vincent C.O. Njar, Thangavel Arunachalam, Gerhard Spiteller, Eliahu Caspi

Journal:

Journal of Steroid Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 632 KB

english, 1988

Concerning the pathway from 19-oxoandrost-4-ene-3,17-dione to estrone

Eliahu Caspi, Vincent C.O. Njar

Journal:

Vincent C.O. Njar, Jörg Düerkop, Rolf W. Hartmann

Année:

1987

Langue:

english

Fichier:

PDF, 721 KB

english, 1987

Synthesis of 10β-(1′-azirinyl)estr-4-en-3,17-dione as an aromatase inhibitor

Journal:

Venkatesh D. Handratta, Danijela Jelovac, Brian J. Long, Ritesh Kataria, Ivo P. Nnane, Vincent C.O. Njar, Angela M.H. Brodie

Année:

1996

Langue:

english

Fichier:

PDF, 572 KB

english, 1996

Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 574 KB

english, 2004

CYP17 inhibitors for prostate cancer therapy

Tadas S. Vasaitis, Robert D. Bruno, Vincent C.O. Njar

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 375 KB

english, 2011

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Vânia M.A. Moreira, Tadas S. Vasaitis, Vincent C.O. Njar, Jorge A.R. Salvador

Journal:

Vânia M.A. Moreira, Tadas S. Vasaitis, Zhiyong Guo, Vincent C.O. Njar, Jorge A.R. Salvador

Année:

2007

Langue:

english

Fichier:

PDF, 609 KB

english, 2007

Synthesis of novel C17 steroidal carbamates: Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth

Journal:

Robert D. Bruno, Tadas S. Vasaitis, Lalji K. Gediya, Puranik Purushottamachar, Abhijit M. Godbole, Zeynep Ates-Alagoz, Angela M.H. Brodie, Vincent C.O. Njar

Année:

2008

Langue:

english

Fichier:

PDF, 633 KB

english, 2008

Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model

Journal: